Hyperthermia Dosing and Depth of Effect

Hyperthermia Dosing and Depth of Effect

Szasz Oliver1, Szigeti Gyula Peter2, Vancsik Tamas3, Szasz Andras1

1Department of Biotechnics, St. Istvan University, Budapest, Hungary

2Institute of Human Physiology and Clinical Experimental Research, Semmelweis University, Budapest, Hungary

3Department of Pathology and Experimental Cancer Research, Semmelweis University, Budapest, Hungary


The penetration depth in the electromagnetic heating could be a crucial factor of its application, when the deep heating is the goal. The capacitive coupling is one of the most popular heating techniques in radiofrequency (RF) heating applications. The matching of the target defines the penetration possibilities. The current matched solution has deeper mathematically defined penetration in RF region than the capacitive plane-wave solution. The same power of application

request high voltage with relatively low current for plane-wave inducing, while in current matching it has low voltage with high current. The effective depth of the action in the two solutions do not identical, the penetration defined by the intensity of 1/e portion of the incident beam is higher in the current-matched techniques.


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On the Feynman Ratchet and the Brownian Motor

On the Feynman Ratchet and the Brownian Motor

Gyula Vincze1, Gyula Peter Szigeti2, Andras Szasz1

1Department of Biotechnics, St. Istvan University, Budapest, Hungary

2Institute of Human Physiology and Clinical Experimental Research, Semmelweis University, Budapest, Hungary


We study the Brownian ratchet conditions starting with Feynman’s proposal. We show that this proposal is incomplete, and is in fact non-workable. We give the correct model for this ratchet.

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Symposium for Hyperthermia in Cancer Treatment

The annual KOSG was in Korea 29.11.2017. The symposium was held in Chungnam University Hospital. 

Prof. Szasz and Dr. Carrie Minnaar presented their lectures: 

  • Basic principle and new results of Oncothermia
  • The addition of mEHT to treatment protocols for locally advanced cervical cancer patients

On the Self-Similarity in Biological Processes

On the Self-Similarity in Biological Processes
Oliver Szasz1, Gyula Peter Szigeti2, Andras Szasz1
1Biotechnics Department, St. Istvan University, Godollo, Hungary
2Institute of Human Physiology and Clinical Experimental Research, Semmelweis University, Budapest, Hungary                                                                     

Email: Szasz.Andras@gek.szie.hu


We show that the processes described by Avrami functions are self-similar. A comparative function characterizes a self-similar process by a certain Avrami exponent. We define the self-similar categories of some well-known biological processes. The method to determine the Avrami exponent by choosing the comparative function is demonstrated on the diffusion model of the growth of nuclei. We generalize the results.

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CONGRESSO 2017 art – Prof.András Szász was invited to hold a lecture

Prof.András Szász was invited to hold a lecture about

Abscopal and immune-effects with modulated electrohyperthermia

during the CONGRESSO 2017 art at Lisbon.


Abscopal and immune-effects with modulated electrohyperthermia


Andras Szasz

Department of Biotechnics, St. Istvan University, Hungary (Szasz.Andras@gek.szie.hu)



Most of the radiation therapies act locally. The local control of the tumor is usually not enough for elongation of the survival time because the malignancy is systemic. The abscopal effect, together with immune-stimuli could extend the local method to systemic and could be effective against macro- and micrometastases, too. Our objective is presenting the abscopal effect of modulated electro-hyperthermia (mEHT, oncothermia).


Oncothermia (mEHT) uses amplitude modulated non-ionizing radiofrequency in medical frequency standard (13.56 MHz). This technology is precisely impedance controlled capacitive coupling modulated by the homeostatic time-fractal pattern [1]. mEHT selectively targets the rafts on the membrane of malignant cells [2]. The proper nano-selection [3] uses the well recognizable deviations of metabolic-processes, of cellular connections and of the pathologically different organizing patterns of malignant cells. The nano-range energy absorption ignites particular cell-killing mechanisms. Various in-vitro and in-vivo immune-histochemical studies prove the selection and its effects, and clinical studies showed the increased survival with combined better quality of life.


Significant tumor-cell death caused by mEHT demonstrated by TUNEL. Mitochondrial Bax and release of Cytochrome C, as well as the nuclear translocation of apoptosis-inducing factor AIF, are measured [4]. Immunohistochemistry and apoptosis protein array proved elevated hsp70 and hsp90 membrane expression and released them to the extracellular matrix. Earlier, the cytoplasmic exposure of calreticulin translocated to the cell membrane, and the following release of HMGB1 protein from cell nuclei forms adamage-associated molecular pattern (DAMP), a spatiotemporal set of molecules. The triggered apoptotic processes performimmunogenic cell-death (ICD) [5], which base the genetic transfection of the antigen presenting cells (APC) and realizing tumor-specific immune actions. The abscopal effect is enhanced in consequence of ICD proven by the in-vivo experiments. Using intratumoral dendritic cell (DC) injection together with the mEHT proves the whole body antitumor effects, [6]. Furthermore, mEHTplus DC administration significantly inhibits the tumor growth in other experiments, while even the re-challenging of the tumor inoculation became impossible [7]. In these experiments, the abscopal effect works like a tumor-vaccination. Case reports [8], [9], [10] and prospective clinical trials [11], [12], [13] show a significant increase of the local control together with the survival time compared to the control arm. 



[1] Szasz A et.al. Oncothermia, Springer, 2010

[2] Andocs G. et.al. Biol and Med, 7(4):1-9; 2015

[3] Szasz O, et al. Open Journal of Biophysics 7:116-144, 2017

[4] Meggyeshazi N. et.al. Strahlenther Onkol, 190:815-822; 2014

[5] Andocs G. et.al. Cell Stress and Chaperones, 20:37-46; 2015

[6] Qin W et.al. Oncol Rep 32:2373-2379; 2014

[7] Tsang Y-W et al. BMC Cancer 15:708; 2015

[8] Schirrmacher V, et al. Immunotherapy 7: 855–860, 2015

[9] Schirrmacher V, et.al. Oncology Letters 8:2403-2406, 2014

[10] Jeung TS, et al. Conf. Papers in Medicine, Vol. 2013, Article ID 392480, 2013

[11] Pang CLK, et al. Molecular and Clinical Oncology, 6:723-732, 2017

[12] Minnaar C, et al. Physica Medica 32(2):151-152, 2016

[13] Lee S-Y, et al. Oncology Letters, DOI: 10.3892/ol.2017.6117, 2017

Oncothermia brings new hope to cancer patients

Saudi Gazette

RIYADH — Driven by a great desire to help cancer patients and reduce their suffering, Prof. Andras Szasz, founder and head of research at Oncotherm company, has developed a painless therapy to complement cancer treatment.

Known as oncothermia, it is a modulated-electro-hyperthermia for oncological use. It is a fast developing supportive, complementary treatment method against different types of tumors. The Saudi Food and Drugs Authority recently approved the procedure.

The principles of treatment are based on the classical method of hyperthermia, but the aim, beside the absolute increase in temperature, is especially the direct electric-field energy absorption in the extracellular liquid and destroying the membrane of the cancer cells.

Oncothermia’s effect is synergic to radiotherapy and to numerous chemotherapies. Furthermore, it leads to an increased immunogenicity and effectively reduces the pain of the patient.

Saudi Gazette met with Prof. Szasz, who was on a visit to Riyadh and Jeddah recently and had multiple meetings with stakeholders about his invention and how it helps cancer patients across five continents.

“I started working on my invention since 1988. The journey was very long and it was not easy. There were many trials and errors and countless procedures to make it recognizable,” he said.

“In 2002, we started spreading my invention through my company, which is only responsible for serious medical tasks. Currently, we have spread it in 35 countries and now 200,000 oncothermia procedures are performed annually,” he added.

The invention had produced encouraging results in enhancing the survival time of cancer patients. “The cases treated by oncothermia had shown a 20 percent improvement in the quality of lives for patients. However, we cannot separate the invention from other crucial factors, such as medications and a determination for survival,” he emphasized.

The researcher said oncothermia is absolutely safe and has no side effects. “It can be used for all age groups, female and male, and all types of cancer except leukemia.

I have strong hope that Saudi hospitals will apply this method in treatment,” Szasz said.

Dr. Hamad Al-Omar, chairman of the National Blood and Cancer Center, said there were more than 20,000 new cancer cases in the Kingdom in 2017, in addition to existing patients. “The Ministry of Health is working hard to enhance services given to cancer patients. We held several talks with Prof. Szasz and we hope to adopt this new method in our public and private hospitals,” he said.

Dr. Al-Omar said the main causes of cancer in the Kingdom are smoking, lack of exercise and unhealthy diet. “However, with the new treatment methods, we can think of cancer as a chronic disease, not a fatal disease,” he stressed.

He said cancer can be fully cured while diabetes for example is incurable. “Unfortunately, people think of cancer as a fatal disease that is incurable when the truth is most cancer cases can be cured,” Al-Omar said.

He emphasized that prevention is much better than cure. “By adopting a healthy lifestyle, we can reduce the possibility of us getting diseases. If we look back 10 years, diabetes affected only 5 percent of people while today it is 30 percent, all because of the unhealthy lifestyles,” he concluded.